Act as a convergence point for multiple signals that control autophagy, and can bind to several autophagy-related (Atg) proteins, regulating phosphorylation states and protein trafficking. AMPK, activated during low nutrient conditions, directly phosphorylates ULK1 at multiple sites including Ser317, Ser555, and Ser777. Conversely, mTOR, which is a regulator of cell growth and an inhibitor of autophagy, phosphorylates ULK1 at Ser757 and disrupts the interaction between ULK1 and AMPK.

Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) ULK1 KIAA0722

Human Mouse Rat,pig,cow,nochicken

WB,IHC,ICC/IF

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

120kDa

ULK1 KIAA0722

o75385

https://www.uniprot.org/uniprotkb/o75385

A synthesized peptide derived from human ULK1

Rabbit

Monoclonal

Rabbit IgG

ULK1 Antibody detects endogenous levels of total ULK1

Autophagy

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2936433