HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) HMGA1 HMGIY

Human Mouse Rat

WB,IHC,ICC/IF,FCM

WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50

17kDa

HMGA1 HMGIY

p17096

https://www.uniprot.org/uniprotkb/p17096

A synthesized peptide derived from human HMGA1

Rabbit

Monoclonal

Rabbit IgG

HMGA1 Antibody detects endogenous levels of total HMGA1

Nucleus localization

regulation of DNA-templated transcription,

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.