Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity).

Histone H2ALOC107800855

Nicotiana tabacum

WB

WB 1:1000-1:2000； IHC/IF 1:50-1:500

15kDa(Calculated).

LOC107800855

A0A1S4AS66

https://www.uniprot.org/uniprotkb/a0a1s4as66

Mouse

Monoclonal

Mouse IgG

H2A.X Antibody detects endogenous levels of total H2A.X.

Nucleus localization

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.Store at -20°C long term.