Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) SMC5 KIAA0594 SMC5L1

Human

ELISA, WB

ELISA, WB; Recommended dilution : WB:1:500-1:5000

128.806 kDa ;

SMC5 KIAA0594 SMC5L1

Q8IY18

https://www.uniprot.org/uniprotkb/q8iy18

Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)

Rabbit

Polyclonal

IgG

Nucleus localization

Epigenetics and Nuclear Signaling; Cell biology

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Store at -20°C. Do not aliquot the antibody