Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. .

Interleukin-1 beta (IL-1 beta) Il1b

Mouse;Rat

IHC,WB

Western blotting: 0.5-2μg/mL; Immunohistochemistry: 5-20μg/mL; Immunocytochemistry: 5-20μg/mL;Optimal working dilutions must be determined by end user.

30.644kD;

Il1b

Q63264

https://www.uniprot.org/uniprotkb/q63264

RKRA56395-Recombinant Interleukin 1 Beta (IL1b) Val117~Ser268

Mouse

Monoclonal

Mouse IgG

Cytokine;Tumor immunity;Infection immunity;

Protein A + Protein G affinity chromatography

Liquid

1mg/mL

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.