Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues. Caspase-9 belongs to a family of caspases, cysteine-aspartic proteases involved in apoptosis and cytokine signalling. Regulation of Caspase-9 occurs through phosphorylation by an allosteric inhibitor, inhibiting dimerization and inducing a conformational change. Correct caspase-9 function is required for apoptosis, leading to the normal development of the central nervous system. Without correct function, abnormal tissue development can occur leading to abnormal function, diseases and premature death. Different protein isoforms of caspase-9 are produced due to alternative splicing.

Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] CASP9 MCH6

Human Mouse

WB,IHC,IF,IP

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

46,39,37,35kDa

Caspase-9

P55211

https://www.uniprot.org/uniprotkb/p55211

Rabbit

Monoclonal

Rabbit IgG

Apoptosis #DNA damage

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2936282