13162017139（微信同号）
13162017139（微信同号）
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. .
MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) MKNK1 MNK1
Human,Mouse
IHC,IF
52kD
MKNK1 MNK1
Q9BUB5
Rabbit
Polyclonal
Rabbit IgG
Translation regulation
Product Information
| Description | MNK1rabbit polyclonal |
| Protein full name | MAP kinase-interacting serine/threonine-protein kinase 1 |
Synonyms | MAP kinase signal-integrating kinase 1, MAPK signal-integrating kinase 1, Mnk1, Mknk1, Mnk1 |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse MNK1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cytoplasm,Nucleus |
| Uniprot ID |
Applications
| Applications | IHC | IF |
| Species | Human,Mouse | Human,Mouse |
| Dilution | 1:1000-1:2000 | 1:1000-1:2000 |
| Positive tissue | lung cancer, liver cancer, colon cancer, colon, tonsil, brain | ovary, liver, brain striatum, lung |
Background
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G.
Images
| Immunohistochemistry analysis of paraffin-embedded human lung cancerusing MNK1 (T611286M) at dilution of 1:1000 |
| Immunohistochemistry analysis of paraffin-embedded human liver cancerusing MNK1 (T611286M) at dilution of 1:1000 |
| Immunohistochemistry analysis of paraffin-embedded human colon cancerusing MNK1 (T611286M) at dilution of 1:1000 |
| Immunohistochemistry analysis of paraffin-embedded human colonusing MNK1 (T611286M) at dilution of 1:1300 |
| Immunohistochemistry analysis of paraffin-embedded human tonsilusing MNK1 (T611286M) at dilution of 1:1300 |
| Immunohistochemistry analysis of paraffin-embedded mouse brainusing MNK1 (T611286M) at dilution of 1:1300 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedhuman ovaryusing MNK1 (T611286M) at dilution of 1:1300 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedhuman liverusing MNK1 (T611286M) at dilution of 1:1300 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedmouse brain striatumusing MNK1 (T611286M) at dilution of 1:1300 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedmouse lungusing MNK1 (T611286M) at dilution of 1:1300 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
艾比玛特医药科技（上海）有限公司
上海市徐汇区桂平路333号聚科生物园区1号楼1-3层
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13162017139（微信同号）
技术支持：15618194176（微信同号）
南方经销商负责：手机13122837132(微信同号)
北方及西南经销商负责：手机13122150513(微信同号)
微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13162017139（微信同号）
技术支持：15618194176（微信同号）
总机：021-34695901
南方经销商负责：手机13122837132(微信同号)
北方及西南经销商负责：手机13122150513(微信同号)
微信客服
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