Paired box (PAX) proteins are a family of transcription factors that play important and diverse roles in animal development. Nine PAX proteins (PAX1-9) have been described in humans and other mammals. They are defined by the presence of an amino-terminal paired domain, consisting of two helix-turn-helix motifs, with DNA binding activity. PAX proteins are classified into four structurally distinct subgroups (I-IV) based on the absence or presence of a carboxy-terminal homeodomain and a central octapeptide region. Subgroup I (PAX1 and 9) contains the octapeptide but lacks the homeodomain; subgroup II (PAX2, 5, and 8) contains the octapeptide and a truncated homeodomain; subgroup III (PAX3 and 7) contains the octapeptide and a complete homeodomain; and subgroup IV (PAX4 and 6) contains a complete homeodomain but lacks the octapeptide region. PAX proteins play critically important roles in development by regulating transcriptional networks responsible for embryonic patterning and organogenesis; a subset of PAX proteins also maintain functional importance during postnatal development. Research studies have implicated genetic mutations that result in aberrant expression of PAX genes in a number of cancer subtypes (1-3), with members of subgroups II and III identified as potential mediators of tumor progression.

Paired box protein Pax-3 (HuP2) PAX3 HUP2

Human,Mouse,Rat

WB,IHC

Western blotting 1:500-1:2000 IHC/IF 1 :50 -1:1000

53kD

PAX3 HUP2

P23760

A synthesized peptide derived from human PAX3, corresponding to a region within the internal amino acids.

Rabbit

Polyclonal

Rabbit lgG

PAX3 Antibody detects endogenous levels of total PAX3.

Apoptosis #Myogenesis #Neurogenesis #Hearing

PBS,pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.