Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.

Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) SQSTM1 ORCA OSIL

Human Mouse Rat

WB,ICC/IF,FCM

WB 1:5000~1:10000 ICC/IF 1:50~1:200 FC 1:50

62kDa

SQSTM1 ORCA OSIL

q13501

https://www.uniprot.org/uniprotkb/q13501

A synthesized peptide derived from human p62/SQSTM1

Rabbit

Monoclonal

Rabbit IgG

p62/SQSTM1 Antibody detects endogenous levels of total p62/SQSTM1

Apoptosis #Autophagy #Differentiation #Immunity

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2936967