细胞因子-Recombinant CXCL4 (C-X-C motif chemokine 4), Human ,AF

Datasheet

Synonym/Alternative Name(s)收起

Platelet Factor-4,PF-4, Oncostatin A, Ironplact

Activity收起

Measure by its ability to inhibit human FGF-2-induce proliferation in HUVEC cells.
The ED50 for this effect is <5 μg/mL.

Protein Description收起

CXCL4, also known as platelet factor 4 (PF-4), is one of the most plentiful platelet chemokines.Depending on the cell type, CSCL4 may has several biological functions. CXCL4 is mainly produced in megakaryocytes, released from the α-granules of platelets as a tetramer at micromolar concentrations depending on platelet activation. CXCL4 has both procoagulant and anticoagulant activities, thereby can bind heparin and neutralize the anticoagulant effect of heparin. In addition, CXCL4 also have functions such as inhibiting factor XII, and vitamin K dependent coagulation factor, and stimulating activated protein C generation. As a strong tumor inhibitor, CXCL4 can inhibit endothelial cell migration, proliferation, and in vivo angiogenesis through interfering with the angiogenic effect of growth factors such as FGF and VEGF.

Protein Accession收起

P02776.2

Gene Symbol收起

5196

Expression Region收起

EAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES with polyhistidine tag at the N-terminus.

Tag收起

His-tag at the N-terminus

Species收起

Human

Reactivity收起

Human

Expression Source收起

Escherichia coli

Source收起

E. coli

Purification收起

>98% as determined by SDS-PAGE. Ni-NTA chromatography

Endotoxin收起

<0.1 EU per 1 μg of the protein by the LAL method.

Calculated Mol Weight收起

8.58 kDa

Formulation收起

The protein was lyophilized from a solution containing 1X PBS, pH 7.4.

Reconstitution收起

It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Shipping收起

Blue Ice

Storage Condition收起

Lyophilized protein should be stored at -20°C for 1 year.
Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1%
BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months.

Category收起

Cytokines

Application收起

Cell culture, Elisa

Image收起

SDS- PAGE analysis of recombinant human CXCL4

References

RMCH162

货号 规格 价格(¥)
RMCH162S 5ug 780
RMCH162M 20ug 1,800
RMCH162L 100ug 5,400
RMCH162H 500ug 15,600

以上产品均有现货供应

订购咨询 orders@ab-mart.com

订货热线 4006-123-828

技术支持15618194176

经销商名录:点击查看


Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

艾比玛特医药科技(上海)有限公司
上海市徐汇区桂平路333号聚科生物园区1号楼1-3层

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13162017139(微信同号)

技术支持:15618194176(微信同号)

南方经销商负责:手机13122837132(微信同号)          
北方及西南经销商负责:手机13122150513(微信同号)

6380582812748833035900295.jpg

微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13162017139(微信同号)

技术支持:15618194176(微信同号)

总机:021-34695901

南方经销商负责:手机13122837132(微信同号)          
北方及西南经销商负责:手机13122150513(微信同号)

6380582812748833035900295.jpg

微信客服

沪ICP备17056956号-2    艾比玛特医药科技(上海)有限公司