分子量

160.17

储存条件

3年-20°C 粉状
2年-80°C 溶于溶剂

化学式

C6H12N2O3

CAS号

1596-84-5

别名

Aminozide, DMASA, DIMG, B 995, Alar，Kylar，B-NINE, SADH

化学名

Butanedioic acid, 1-?(2,?2-?dimethylhydrazide)

Solubility (25°C) *

体外

DMSO

32 mg/mL (199.78 mM)

体内（现配现用）

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

浓度 / 溶剂体积 / 质量

1 mg

5 mg

10 mg

1 mM

6.2434 mL

31.2168 mL

62.4337 mL

5 mM

1.2487 mL

6.2434 mL

12.4867 mL

10 mM

0.6243 mL

3.1217 mL

6.2434 mL

50 mM

0.1249 mL

0.6243 mL

1.2487 mL

产品描述

Daminozide, a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily with IC50 of 1.5±0.7 μM for KDM2A. It is at least 100-fold selective as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members tested, with IC50s of 2 μM or less against KDM2A, PHF8, and KIAA1718 and IC50s of 127 μM for KDM3A or greater (mM range) against other demethylases.

靶点/IC50

PHF8

KDM2A

0.55 μM

1.5 μM

体外研究

体内研究