分子量

392.24

储存条件

3年-20°C 粉状
2年-80°C 溶于溶剂

化学式

C18H15Cl2N3O3

CAS号

2243736-45-8

别名

N/A

化学名

Benzamide, 2-?[[2,?6-?dichloro-?4-?(3,?5-?dimethyl-?4-?isoxazolyl)?phenyl]?amino]?-?N-?hydroxy-

Solubility (25°C) *

体外

DMSO

78 mg/mL (198.85 mM)

Water

Insoluble

Ethanol

Insoluble

体内（现配现用）

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

浓度 / 溶剂体积 / 质量

1 mg

5 mg

10 mg

1 mM

2.5495 mL

12.7473 mL

25.4946 mL

5 mM

0.5099 mL

2.5495 mL

5.0989 mL

10 mM

0.2549 mL

1.2747 mL

2.5495 mL

50 mM

0.0510 mL

0.2549 mL

0.5099 mL

产品描述

FB23-2 是一种有效的、具有选择性的 FTO 的抑制剂，可直接与FTO结合并选择性抑制FTO的 N6-methyladenosine (m6A) 去甲基酶的活性，其IC50值为2.6 μM。

靶点/IC50

FTO, IC50:  2.6 μM

体外研究

FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells.
FB23 inhibits the proliferation of NB4 and MONOMAC6 cells, with IC50 values of 0.8 μM and 1.5 μM.

体内研究

FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice.