Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).

Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) KDM2B CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2

Human, Mouse, Rat

WB,IP,IF

WB 1:500-1:2000, IHC 1:50-1:200; IP 1:50-1:100

167KD

KDM2B CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2

Q8NHM5

https://www.uniprot.org/uniprotkb/q8nhm5

Mouse

Monoclonal

Mouse IgG

Nucleus localization

Spermatogenesis

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.