表观产品-小分子抑制剂-ASXL2 Antibody

Datasheet

Description

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.

Uniprot

Q76L83

Alternative Names

additional sex combs like 2; additional sex combs like transcriptional regulator 2; Additional sex combs-like protein 2; polycomb group protein ASXH2; Putative Polycomb group protein ASXL2; ASXH2; ASXL2; KIAA1685;

Reactivity

Human, Mouse, Rat

Source

Mouse

Application

Mol Weight

159KD

Storage Condition

Store at -20 °C. Stable for 12 months from date of receipt.

Application

WB 1:500-1:2000, IHC 1:50-1:200; IP 1:50-1:100

M30166

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