May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity).

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11) ALKBH7 ABH7 SPATA11 UNQ6002/PRO34564

Human, Mouse, Rat

WB,IP,IF

WB 1:500-1:2000, IHC 1:50-1:200; IP 1:50-1:100

24KD

ALKBH7 ABH7 SPATA11 UNQ6002/PRO34564

Q9BT30

https://www.uniprot.org/uniprotkb/q9bt30

Mouse

Monoclonal

Mouse IgG

DNA damage #Fatty acid metabolism

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.