Lysine acetylation is an important reversible modification controlling protein activity In various species, acetylation of lysine residues is an important form of protein posttranslational modification(PTM)that affects thousands of proteins such as Histones, transcript factors, IFN receptors, as well as P53, tubulin, Hsp9o that ranging from nuclear regulators to cytosolic proteins, mitochondrial enzymes, and plasma membrane associated receptors(1) The regulation of protein acetylation is involved in control of cell cycle, metabolism, cell signaling, nuclear transport and even other PTM process (1, 2, 3) [1]: Xiang-jiao Y et al. (2008)Molecular Cell 31, 449-461 [2]: Choudhary C et al. (2014) Nature Reviews Molecular Cell Biology 15, 536-550 [3]: Choudhary, C et al. (2009) Science 325. 834-40
Target Acetylated-lvsine Host Reactivity All spe Isotype Mouse lag
Immunoprecipitation >10oug antibody with 5oul Cnbr-sepharose 4B/Protein A Sepharose beads Western Blot 1:200-1:1000
Fig 1 Western blot analysis of chemical acetylated 293T tot Fig2 Relative distribution of acetylated proteins with lysate(Ioug lane 1) un-acetylated 293T total lysate (10 g, lane diverse biological process identified from an immun 2), chemical acetylated BSA (5ng, lane 3) and un-acetylated precipitation LC-MS/MS experiment of mouse liver BSA(5ng, lane 4). using Abmart Acetylated-lysine Mab at a tissue using Acetylated-lysine Mab 1: 1000 dilution Additional information Please add Milli-q water or Abmart solution buffer to the tube before use, at the concentration ofl mg/ml O 2016 Abmart(Shanghai)Co, Ltd
Store at -20°C long term.
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