表观产品-小分子抑制剂-Histone H2A.X Antibody

Datasheet

Description:

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.






Uniprot:

P16104


Alternative Names:

AW228881; H2A histone family member X; H2A.FX; H2A.X; H2a/x; H2AFX; H2AX; H2AX histone; H2AX_HUMAN; Hist5.2ax; Histone 2A; Histone 2AX; Histone H2A.X; Histone H2AX; RGD1566119;






Specificity:

Histone H2A.X Antibody detects endogenous levels of total Histone H2A.X.






Reactivity:

 Human, Mouse, Rat


Source:

Mol.Wt.:

15 kDa


Storage Condition:

Store at -20 °C. Stable for 12 months from date of receipt.


Application:

WB 1:1000-1:2000;IHC/IF 1:50-1:500

image.png

Western blot analysis of extracts from 293T cell lysate, using Histone H2A.X Antibody.


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Storage Condition

Store at -20°C long term.

M020534

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