The most prominent clinical syndrome associated with a disordered hypersecretion of Calcitonin (CT) is medullary carcinoma of the thyroid (MTC). MTC is a tumor of the Calcitonin producing C-cells of the thyroid gland. Although MTC is rare, comprising 5 - 10% of all thyroid cancer, it is often fatal. Further, it leant itself to be diagnosed early by serum Calcitonin and total cure for early sub-clinical disease is possible. Neoplastic disorders of other neuroendocrine cells can also elevate Calcitonin. The best example is small cell lung cancer. Other tumors such as carcinoids and islet cell tumors of the pancreas can also result in elevated serum Calcitonin. Increases in serum Calcitonin has also been noted in both acute and chronic renal failure, hypercalciuria and hypercalcemia.

Calcitonin

Calcitonin, CT

P01258

This Abmart monoclonal antibody is produced by immunizing mice with a Synthetic peptide corresponding to the amino acids 16-32 of human Calcitonin, conjugated to a high molecular weight carrier

Mouse IgG2b

Human

ELISA                       1: 50000--1:1000OOO

Stored at -20°C or below until use. Avoid repeated freezing and thawing cycles.