细胞因子-Recombinant CXCL4 (C-X-C motif chemokine 4), Human ,AF

Datasheet

Synonym/Alternative name(s)

Platelet Factor-4,PF-4, Oncostatin A, Ironplact

Activity

Measure by its ability to inhibit human FGF-2-induce proliferation in HUVEC cells.
The ED50 for this effect is <5 μg/mL.

Protein Description

CXCL4, also known as platelet factor 4 (PF-4), is one of the most plentiful platelet chemokines.Depending on the cell type, CSCL4 may has several biological functions. CXCL4 is mainly produced in megakaryocytes, released from the α-granules of platelets as a tetramer at micromolar concentrations depending on platelet activation. CXCL4 has both procoagulant and anticoagulant activities, thereby can bind heparin and neutralize the anticoagulant effect of heparin. In addition, CXCL4 also have functions such as inhibiting factor XII, and vitamin K dependent coagulation factor, and stimulating activated protein C generation. As a strong tumor inhibitor, CXCL4 can inhibit endothelial cell migration, proliferation, and in vivo angiogenesis through interfering with the angiogenic effect of growth factors such as FGF and VEGF.

Protein Accession

P02776.2

Gene ID

5196

Application

Expression Region

EAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES with polyhistidine tag at the N-terminus.

Tag

His-tag?at?the?N-terminus

Species

Human

Reactivity

Human

Expression Host

Escherichia coli

Source

E. coli

Purification

>98% as determined by SDS-PAGE. Ni-NTA chromatography

Endotoxin

<0.1 EU per 1 μg of the protein by the LAL method.

Calculated Molecular Weight

8.58 kDa

Formulation

The protein was lyophilized from a solution containing 1X PBS, pH 7.4.

Reconstitution

It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Shipping

Blue Ice

Stability and Storage

Lyophilized protein should be stored at -20°C for 1 year.
Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1%
BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months.

Category

Cytokines

Application

Cell culture, Elisa

Image

SDS- PAGE analysis of recombinant human CXCL4

RMCH162

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RMCH162S 5ug
RMCH162M 20ug
RMCH162L 100ug
RMCH162H 500ug

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13162017139(微信同号)

技术支持:13162477137(微信同号)

总机:021-34695901

经销商:QQ 402772198
南方经销商负责:手机13122837132(微信同号)          
北方及西南经销商负责:手机13122150513(微信同号)

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