Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by the HDAC1 gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Histone deacetylase 1

HDAC1; Histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1

Q13547

55kDa

This Abmart polyclonal antibody is produced by immunizing animals with a synthetic peptide (Abmart SEAL mAb technology) corresponding to HDAC1 protein.

Rabbit IgG

Human, Mouse, Rat

Western blotting                           1:1000-1:2000

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.