Vinculin is a membrane-cytoskeletal protein in humans that is encoded by the VCL gene. Vinculin is associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Vinculin's ability to interact with integrins appears to be critical for control of cytoskeletal mechanics, cell spreading, and lamellipodia formation. Thus, vinculin appears to play a key role in shape control based on its ability to modulate focal adhesion structure and function.

Vinculin (Metavinculin) (MV) VCL

Human, Mouse, Rat

Monkey,Dog,Pig,Cat,Horse,Sheep,Bovine,Rabbit,Hamster,Guinea Pig,Chicken,Xenopus,Zebrafish

WB

Western blotting 1:1000-1:3000

125kDa

Vinculin

P18206

https://www.uniprot.org/uniprotkb/p18206

Rabbit

Polyclonal

Rabbit IgG

Cell adhesion

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2936321