Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.MiscellaneousThis histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).

H3C1

H3 histone; HIST1H3A; Histone cluster 1; H3a

P68431

Mouse

Monoclonal Antibody

IgG1

Recombinant Protein of Histone H3

Human,Mouse,Rat,Yeast

WB: 1/5000-1/10000 IHC: 1/50-1/200 IF: 1/100-1/200 IP: 1/20

Calculated MW: 15 kDa; Observed MW: 15 kDa

Affinity Purified

Liquid

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Store at 4°C short term. Store at -20°C long term. Avoid freeze/thaw cycles.