Paired box (PAX) proteins are a family of transcription factors that play important  and diverse roles in animal development. Nine PAX proteins (PAX1-9) have been described in humans and other mammals. They are defined by the presence of an  amino-terminal paired domain, consisting of two helix-turn-helix motifs, with DNA  binding activity. PAX proteins are classified into four structurally distinct subgroups  (I-IV) based on the absence or presence of a carboxy-terminal homeodomain and a  central octapeptide region. Subgroup I (PAX1 and 9) contains the octapeptide but  lacks the homeodomain; subgroup II (PAX2, 5, and 8) contains the octapeptide and a  truncated homeodomain; subgroup III (PAX3 and 7) contains the octapeptide and a  complete homeodomain; and subgroup IV (PAX4 and 6) contains a complete  homeodomain but lacks the octapeptide region. PAX proteins play critically  important roles in development by regulating transcriptional networks responsible for  embryonic patterning and organogenesis; a subset of PAX proteins also maintain  functional importance during postnatal development. Research studies have  implicated genetic mutations that result in aberrant expression of PAX genes in a  number of cancer subtypes (1-3), with members of subgroups II and III identified as  potential mediators of tumor progression.

CDHS; HUP 2; HUP2; MGC120381; MGC120382; MGC120383; MGC120384;  MGC134778; Paired box 3; Paired box gene 3; Paired box homeotic gene 3; Paired box  protein Pax 3; Paired box protein Pax-3; Paired box protein Pax3; Paired domain gene  3; Paired domain gene HuP2; PAX 3; Pax3; PAX3/FKHR fusion gene;  PAX3_HUMAN; Sp; splotch; Waardenburg syndrome 1; WS 1; WS1; WS3

A synthesized peptide derived from human PAX3, corresponding to a region within the  internal amino acids.

Rabbit lgG

PAX3 Antibody detects endogenous levels of total PAX3.

Human,Mouse,Rat

Western blotting    1:500-1:2000 

IHC/IF                  1 :50 -1:1000

Store at -20℃ Stable far one year from the date of shipment.