PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis.(Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
Cardiolipin activated protein kinase Pak2; MGC150606; MGC71074; PAK 2; PAK2; PKN gamma; PKN2; PKN2_HUMAN; PRK2; PRKCL2; PRO2042; Protein kinase C like 2; Protein kinase C related kinase 2; Protein kinase C-like 2; Protein kinase N2; Protein-kinase C-related kinase 2; Serine/threonine-protein kinase N2;
Q16513
140kD; 112kDa(Calculated).
Mouse
PRK2 antibody detects endogenous levels of total PRK2.
Human, Mouse, Rat, Monkey
WB,IHC,ELISA,FCM
Recommended dilution
WB 1:500-1:2000 IHC 1:50-1:500 ELISA 1:2000 FCM 1:50
Store at -20 °C. Stable for 12 months from date of receipt.
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
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邮箱:market@ab-mart.com
应聘职位:hr@ab-mart.com
订购专线:4006-123-828
销售电话:13162017139(微信同号)
技术支持:13162477137(微信同号)
总机:021-34695901
经销商:QQ 402772198
南方经销商负责:手机13122837132(微信同号)
北方及西南经销商负责:手机13122150513(微信同号)
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