补体Complement-MASP1 Antibody

Datasheet

Description

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343).

Uniport

P48740

Alternative Names

Complement-activating component of Ra-reactive factor [Precursor], EC 3.4.21.-, Ra-reactive factor serine protease p100, RaRF, Mannan-binding lectin serine protease 1, Mannose-binding protein-associated serine protease, MASP-1, Serine protease 5, Compleme

Reactivity

Human

Source

Mouse monoclonal

Application

Mol Weight

76kDa

Storage

Store at -20 °C. Stable for 12 months from date of receipt.

Application

WB 1:500-1:2000

M053388

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