Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity).

H2A histone family member X; H2A.FX; H2A.X; H2a/x; H2AFX; H2AX; H2AX histone; Hist5.2ax; Histone 2A; Histone 2AX; Histone H2A.X; Histone H2AX;

A0A1S4AS66

15kDa(Calculated).

Mouse

H2A.X Antibody detects endogenous levels of total H2A.X.

Nicotiana tabacum

WB 1:1000-1:2000；IHC/IF 1:50-1:500 

Western blot analysis of H2AX using Nicotiana tabacum leaf lysates

Store at -20 °C. Stable for 12 months from date of receipt.