This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.

Hyaluronoglucosaminidase; Cell migration-inducing hyaluronidase 2; Cell surface hyaluronidase; Transmembrane protein 2; CEMIP2; KIAA1412; TMEM2;

G0ZDN6

154kDa

Mouse monoclonal

Zebrafish

WB 1:500-1:2000

Store at -20 °C. Stable for 12 months from date of receipt.