Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development. Three structural vinculin domains include an amino-terminal head, a short, flexible proline-rich region and a carboxy-terminal tail. In the inactive state, the head and tail domains of vinculin interact to form a closed confirmation. The open and active form of vinculin translocates to focal adhesions where it is thought to be involved in anchoring F-actin to the membrane and regulation of cell migration.
Vinculin (Metavinculin) (MV) VCL
Human Mouse Rat
WB,ICC/IF,IP
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50
125kDa
VCL
p18206
A synthesized peptide derived from human Vinculin
Rabbit
Monoclonal
Rabbit IgG
Vinculin Antibody detects endogenous levels of total Vinculin
Cell adhesion
Affinity-chromatography
PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
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