Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity).

Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha) LEF1

Human Mouse Rat

WB,IHC,ICC/IF

WB: 1:1000~1:2000 IHC: 1:50~1:200 ICC/IF: 1:100~1:500 IP: 1:50 FC: 1:50

44kDa

LEF1

q9uju2

https://www.uniprot.org/uniprotkb/q9uju2

A synthesized peptide derived from human LEF1

Rabbit

Monoclonal

Rabbit IgG

LEF1 Antibody detects endogenous levels of total LEF1

Nucleus localization

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2935665