Plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1; the activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, then from E2 to ubiquitin ligase E3 for final delivery to the epsilon-NH2 of the target protein lysine residue.

Polyubiquitin-B [Cleaved into: Ubiquitin] UBB

Human Mouse Rat

WB,IHC,ICC/IF,FCM

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50

26kD

UBB

p0cg47

https://www.uniprot.org/uniprotkb/p0cg47

A synthesized peptide derived from human Ubiquitin

Rabbit

Monoclonal

Rabbit IgG

Ubiquitin Antibody detects endogenous levels of total Ubiquitin

Affinity-chromatography

PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

AB_2936388